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Gram-negative bacteria mostly from Enterobacteriaceae family are multidrug resistance and contributing to the antibiotic resistance problems worldwide. Enterobacteriaceae resistance against antibiotics especially β-lactam type is progressively controlled by the organization of constantly expressed genes that code effective drug modifying enzymes. Strong and excessive selection pressure has deceptively been complemented by a transfer from “natural” resistance, such as membrane impermeability, and drug efflux, to the modern pattern of mobile gene pools that mostly decide the epidemiology of modern antibiotic resistance. Escherichia coli is recognized as a pathogen of fecal contamination, its presence in food shows the expected occurrence of other enteric pathogens. The current review focuses on drug-resistant E. coli that are harder to treat with common antibiotics, different ways of multi drug resistance in E. coli and the possible alternative therapeutic procedures for prevention and treatment of these bacteria.
Keywords: Antimicrobials; Community health; Nosocomial infections; Pathogenesis; Superbugs