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Two villages were selected from District Dera Ismail Khan, Kot Sigger at the bank of river Indus and Daraban in the Daman to find out comparative prevalence of Liver fluke and efficacy of anthelmintic (oxfendazole) drugs. 50 sheep were selected from each village and after pretesting, total 32 infested sheep were further randomly divided into 4 equal groups A, B, C and D. Group A were treated with Oxfenda SC (ICI) 1ml per 10kg b.w P.O. Group B was treated with oxfenda SC 1ml/10kg in combination with dimadin (Nawan pharma) at 30ml/50kg b.w P.O. In Group C (control positive) sheep 5% glucose were given I.V and in Group D, no drug was used. Faecal and haematological result of each experimental group was examined day 0, 7 and 28. Prevalence of fasciolosis in sheep was 70% in village Kot Sigger located at the bank of river Indus as compared to Daraban 34%. Group B sheep treated with two drug combination (oxfenda SC & dimadin) showed 75% efficacy as compared to Group A 50% treated only with Oxfenda SC. At day 0 of the infected group there is significant drop in (p<0.05) RBC and HB whereas there was no significant difference found in all groups at day 28. The WBC values were not same in all groups during the treatment, but values become normal after treatment in infested sheep. Similarly the ALT and AST were significantly high (P<0.05) at day 0 but after treatment the values were same as of control group.
Keywords: Anthelmintic; Liver fluke; Population; Prevalence; Ovis aries Sheep