22. Antibacterial activity of Momordica charantia L. and Citrus limon L. on gram positive and gram negative bacteria

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Zaheer Ahmed, Agha Asad Noor


The uses of herbal medicines are well recognized since the advent of mankind having very little side effects. Their use is a cheaper and quite affordable source of antimicrobial particularly in the rural areas. Some of the microbial strains are drug resistant and are always been a threat to human life. The herbal therapy is the best choice of remedy against the drug-resistant strains, which had opened the new roads for conventional use due to several antimicrobial phytochemicals and essential oils. Momordica charantia Linnaeus (L). and Citrus limon L. contain phytochemicals, which affect the bacteria, fungi, viruses, and parasites The aim of this study is to examine the effects of Momordica charantia and Citrus limon peel extracts on gram-positive and gram-negative bacteria. Preparation of extracts in ethanol, methanol, and ether were prepared and activation of test cultures, antimicrobial assay by disc diffusion, well diffusion and spectrophotometry at 600 nm. The greater zones of inhibition were determined by ethanolic extract of  Momordica charantia on the growth of Bacillus cereus and Pseudomonas aeruginosa whereas Citrus limon methanolic peel extract revealed the greater effects on Staphylococcus aureus, Streptococcus pyogenes, and Escherichia coli at 15 and 20 µl concentrations respectively. The observations concluded that both the plant extracts have effects on bacteria that indicate that the preparations of these extracts up to pharmaceutical standard may be effectively used as antibacterial therapy against gram-positive and gram-negative bacteria.

Keywords: Citrus limon peel; G+ve and G-ve bacteria; Momordica charantia; Soxhlet extraction


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