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Hepatitis B Virus (HBV) is a serious worldwide public health issue both in underdeveloped and developed countries. About two billion individuals were infected by HBV globally, of which 400 million were chronic HBV carrier. The aim of this retrospective study was to investigate the seroprevalence and some possible risk factors of hepatitis B virus infection among male blood donors in district Charsadda, Khyber Pakhtunkhwa Pakistan. A total of 460 male blood donors with age range 15-55 years were screened for HBsAg by Immunochromatographic technique (ICT) and 3rd generation enzyme-linked immunosorbent assay (ELISA). Out of 460 samples, 11(2.39%) were found positive for HBsAg by ICT, and 13(2.82%) were HBsAg positive by ELISA. The mean seroprevalence of HBV from both ICT and ELISA was 2.60%. The highest seroprevalence (46.15%) was observed among the donor groups with age range of 21-30 years followed by (30.76%) among 15-20 years, (15.38%) among 31-40 years and the lowest seroprevalence (7.69%) among 41-55 years. Blood transfusion (30.76%) was the most apparent influencing risk factor for HBV followed by dental treatment (23.07%), Sexual partner positive for HBV infection (15.38%), surgery and shave by the barbers (7.69%) for each and unknown reason (15.38%).
Keywords: Hepatitis B virus; ELISA; ICT; Risk factors; Blood donors