100. Evaluation of comparative anti-diabetic effect of guava and mango leaves powder in streptozotocin induced diabetic rats

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Ayesha Riaz, Sana Arif, Rabia Ghaffar Sidra Anam, Riffat Shamim Aslam


Diabetes mellitus is one of the metabolic diseases all over the world. Guava and mango both have nutritious value and also their leaves have medicinal properties. The purpose of this study was to evaluate the comparative anti-diabetic effect of both guava and mango leaves in streptozotocin induced diabetic rats. Bothe guava and mango fruit leaves were purchased from local markets of Faisalabad, dried and grinded. Subsequently, proximate and total phenolic content analysis was performed. Four groups of rats (each with 4 rats) were made to conduct efficacy study. Group A was considered as control group fed with normal diet, group B was fed with guava leaves powder, group C was fed with mango leaves powder, and group D was fed with mixture of both guava and mango leaves powder. Powder was provided to rats on daily bases for 60 days. Parameters including random and fasting blood glucose level, insulin level and lipid profile including total cholesterol, high and low density lipoprotein-cholesterol were checked at the 0 day, 30 day and 60th. The obtained data was subjected to appropriate statistical analysis. The results revealed that there was significant decrease in blood glucose level (fasting + random), cholesterol, and low density lipoprotein, and increase in blood insulin level and high density lipoprotein level indicating effective anti-diabetic effect of guava and mango leaves. Overall comparison indicated the best result in group D. Guava leaves showed better anti-diabetic effect than mango leaves. In conclusion, guava leaves can be suggested for diabetic patients.

Keywords: Anti-diabetic; Blood glucose; Insulin; Metabolic



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