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Chronic kidney disease (CKD) is a worldwide issue. The causes of kidney failure are diabetes, hypertension, pyelonephritis, glomerulonephritis and nephrolithiasis. Kidney transplantation and dialysis are possible solutions of kidney failure. The proportion of kidney failure is increasing worldwidely. Less data available in our community about hemodialysis (HD) having impact on blood parameters especially on hematological parameters. The objective of present study was to determine the effect of haemodialysis on different haematological parameters. This analytical study was conducted at the Institute of Kidney Diseases (IKD), Peshawar on kidney failure patients. A total of 240 blood samples were collected before and after dialysis from 120 haemodialysis patients. Data was analyzed through statistical package for social sciences (SPSS) version 22. In current study, 55.8% were male and 44.1% were female patients with mean age of 40.47±15.27 years. Majority haemodialysis patients with 25.8% were observed in age group range from 26 to 39 years. In present study, Red Blood Cell (RBC), Hemoglobin (Hb), Hemotocrit (HCT), Mean Cell Hemoglobin Concentration (MCHC), Red cell Differential Wedge (RDW), Total Leucocyte Cells (TLC) and Platelets (Plt) were observed significantly decreased in hemodialysis patients than control group whereas only Mean Cell Hemoglobin (MCH) and MCHC were increased in CKD patients than control group. RBC, HB, HCT and MCHC significantly increased in post dialysis as compared to pre-dialysis while TLC and platelets decreased in post dialysis session. It is concluded with present study that hemodialysis has significant effect on haematological parameters. Low level of hemoglobin is a risk factor for hemodialysis patients. This study recommends the screening of hematological parameters before performing hemodialysis.
Keywords: Chronic; Disease; Haematological; Haemodialysis; Kidney; Peshawar