Involvement of vascular endothelial growth factor (VEGF) gene polymorphism in hepatocellular carcinoma of HCV patients from local population

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Muhammad Usman Ghani
Department of Bioinformatics and Biotechnology, Government College University, Faisalabad-Pakistan
Asma Haque, Muhammad Qasim, Usman Ali Ashfaq
Department of Bioinformatics and Biotechnology, Government College University, Faisalabad-Pakistan
Muhammad Sarfaraz Iqbal
Department of Bioinformatics and Biotechnology, Government College University, Faisalabad-Pakistan
Abdul Waheed
Department of Microbiology, University of Health Sciences, Lahore-Pakistan
Nadeem Afzal
Department of Immunology, University of Health Sciences, Lahore-Pakistan
Faiza Saeed
Department of Microbiology, University of Health Sciences, Lahore-Pakistan
Muhammad Shareef Masoud
Department of Bioinformatics and Biotechnology, Government College University, Faisalabad-Pakistan
Saba Khaliq
Department of Physiology, University of Health Sciences, Lahore-Pakistan
Shah Jahan
Department of Immunology, University of Health Sciences, Lahore-Pakistan

Abstract

Development of Hepatocellular carcinoma (HCC) after Hepatitis C virus (HCV) infection is common cause of poor long-term survival. This study aimed to evaluate the effect of Vascular Endothelial growth factor (VEGF) genes polymorphism as a risk factor of Hepatocellular carcinoma (HCC) in chronic hepatitis C virus in Pakistani population. VEGF regulates angiogenesis so it is mainly involved in progression and development of solid tumor. The results showed that HCC patients had a higher frequency of the VEGF-634 GG genotype. In this study results revealed that VEGF Genotype GG is not associated with the risk of HCC in HCV infected patients in Punjab region of Pakistan.


Keywords: HCV; HCC; VEGF Polymorphism


http://dx.doi.org/10.19045/bspab.2017.60077

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Published Jun 10, 2017
Issue
Vol 6 No 2: June-2017
Section
Research Articles

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How to Cite
GHANI, Muhammad Usman et al. Involvement of vascular endothelial growth factor (VEGF) gene polymorphism in hepatocellular carcinoma of HCV patients from local population. Pure and Applied Biology (PAB), [S.l.], v. 6, n. 2, p. 725-732, june 2017. ISSN 2304-2478. Available at: <https://thepab.org/index.php/journal/article/view/131>. Date accessed: 18 apr. 2024.
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