Involvement of vascular endothelial growth factor (VEGF) gene polymorphism in hepatocellular carcinoma of HCV patients from local population

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Muhammad Usman Ghani Asma Haque, Muhammad Qasim, Usman Ali Ashfaq Muhammad Sarfaraz Iqbal Abdul Waheed Nadeem Afzal Faiza Saeed Muhammad Shareef Masoud Saba Khaliq Shah Jahan


Development of Hepatocellular carcinoma (HCC) after Hepatitis C virus (HCV) infection is common cause of poor long-term survival. This study aimed to evaluate the effect of Vascular Endothelial growth factor (VEGF) genes polymorphism as a risk factor of Hepatocellular carcinoma (HCC) in chronic hepatitis C virus in Pakistani population. VEGF regulates angiogenesis so it is mainly involved in progression and development of solid tumor. The results showed that HCC patients had a higher frequency of the VEGF-634 GG genotype. In this study results revealed that VEGF Genotype GG is not associated with the risk of HCC in HCV infected patients in Punjab region of Pakistan.

Keywords: HCV; HCC; VEGF Polymorphism

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