8. Biological evaluation, synthesis and characterization of transition metal complexes of N-Methyl o and p-substituted benzohydroxamic acids

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Bibi Shireen, Naqeebullah Khan, Samiullah, Irshad Ali, Ali Akbar, Attiq-ur-Rehman and Farida Behlil


The four new transition metal complexes as Copper (II), Nickel (II), Cobalt (II) and Cadmium (II) of N-Methyl benzohydroxamate compounds have been prepared by refluxing 2:1 molar ratio of the o- and p-substituted hydroxamic acid ligands along with transition metal salts in hot toluene, using a Dean Stark water separator. The elemental analysis and FT-IR Spectroscopic technique were used to characterizing the hydroxamic acid ligands and its transition metal complexes. Spectroscopic analysis exhibits that the hydroxamic acid ligand behaves as a bidentate chelator and coordinating with metal atom through carbonyl oxygen and deprotonated hydroxyl group. The antibacterial and antifungal activity of hydroxamic acid ligands and their transition metal complexes were evaluated. Transition metal complexes display stronger antibacterial activity than their ligands because of the chelating property of ligands to metal ions and as a result chelation increases the lipophilicity of the complexes. However, ligands and their transition metals complexes did not display any antifungal activity against the Aspergillus Niger (fungus). This study shows that several transition metal complexes are successfully synthesized and these complexes exhibit high antibacterial activity with less toxicity. This research encourages further synthesis of transition metal complexes and the invention of future metal based drugs.

Keywords: Agar well method; Antibacterial activity; Antifungal activity; Coordination; FT-IR; Hydroxamic acids; Metal complexes


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