25. Sero prevalence of anti-tissue transglutaminase in patients having sign symptoms of celiac disease: A cross sectional study from Peshawar, Pakistan
Main Article Content
Abstract
Gluten sensitive enteropathy or more commonly known as celiac disease is one of the auto immune disorder affecting 1% of the individual globally. It is one of the common gastrointestinal disorder in Peshawar, Pakistan and there is scarce of literature available on its prevalence hence this study was aim to determine the seroprevelance of Anti Tissue Transglutaminase (tTG) in patient suspected of celiac dieses and subtype of antibody i.e IgG-IgA contributed towards its seroprevelance. A cross sectional study was conducted on 639 patients having sign symptoms of celiac disease visiting to Rahman medical Institute Peshawar, Pakistan in 2018. Convenient sampling technique were used for selection of samples and screening was done by testing serum Anti tTG IgG and Anti tTG IgA antibody level by Alegria Enzyme linked Immune Sorbent Assay (ELISA) technology. Chi-square test were performed for association between the categorical variable and p value of <0.05 was considered statistically significant. Out of total 639 patients, 57 patients were positive for Anti tTG antibodies and the highest count was observed in age group 0- 20 with frequency of 49 patients. Chi square test reveals no statistically significant difference between gender and seroprevelance of Anti-tTG with a P value of <0.05. The seroprevelance of Anti-tTG were high among age ranges from 1 to 20 years. Anti tTG IgG-IgA contribute for screening of celiac disease, however small bowel biopsy is required for confirmation of diagnosis.
Keywords: Antitissue transglutaminase; Antibodies; Celiac disease; ELISA; Seroprevelance