Oral supplementation of ethanolic extract of Bauhinia variegata leaves did not disturbed the hematological and serum biochemical profile of adult albino mice

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Asmat Ullah, Shahid Iqbal Muhammad Qasim Furhan Iqbal

Abstract

Flower buds, flowers, leaves, stem, seed, roots and stem bark of Bauhinia variegate (B. variegate) are used for pharmacological purposes in various systems such as Homeopathy, Unani, and Ayurveda but little information is available regarding their drug transportation in living systems. Present study was designed to report the effect, if any, of 150 mg/ ml solvent/ Kg body weight of Bauhinia variegata leaf extract on hematology and selected parameters of serum biochemical profile of female and male albino mouse. Seven week old albino mice were weighed and fed orally either with 150 mg/ ml solvent/ kg body weight of Bauhinia variegata leaf extract or saline solution for 17 days. Complete blood count and selected serological parameters were determined in both experimental treatments at the end of dose supplementation. Our results revealed that oral supplementation of 150 mg/ ml solvent/ kg body weight of Bauhinia variegata leaf extract for 17 days did not affected (P > 0.05) any of the studied parameters of complete blood count and serum biochemistry in both female and male albino mice. Hence, it is concluded that 150 mg/ ml solvent/ kg body weight of Bauhinia variegata leaf extract can be safely administrated through oral route in albino mice.


Keywords: Bauhinia variegate; Ethanolic leaf extract; Serum biochemistry; Complete blood count; Albino mice


http://dx.doi.org/10.19045/bspab.2017.60090

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