6. Effect of 1,4-Dioxane on histopathology of heart and muscles of Rabbit Oryctolagus cuniculus

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Sadia Sidra Aziz, Razia Iqbal, Talhat Munir, Izzah Butt, Syeda Iman Fatima, Haleema Zafar


1,4-Dioxane is used in numerous industries e.g. chemicals, pharmaceuticals, detergents, cosmetics, dyes, varnishes, paints, etc. Dioxane occurs frequently in industrial effluents, thus contaminating water bodies and the crops or fields irrigated with 1,4-dioxane contaminated water; and in routinely used synthetic products. It is known causative agent of tumors, cancer and adenomas in animals e.g. rats, mice, guinea pig. For this 45-day study, 52 rabbits were taken and divided in 4 groups: A (control), B (1000mg per kg), C (1500mg per kg), and D (2000mg per kg). Impacts of dioxane on morphology and histopathology of heart, cardiac, smooth and skeletal muscles were studied on day 1, 15, 30 and 45. Lesions were observed around mouth and nose of treated animals. Tumor formation was detected in heart. Histopathological changes include disruption of tissue structure, necrosis, infiltration, invagination of outer tissue boundary and damaged cell structure. Current study provides clear evidence of toxicity and carcinogenicity of dioxane in rabbits.

Keywords: 1,4-Dioxane; Carcinogen; Heart; Histopathology; Muscles; Rabbits


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