18. Histopathological alteration in organs of adult male frog after exposure to alpha-cypermethrin
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Abstract
Alpha-cypermethrin (CYP) is used as an insecticide and indoor residual spray (IRS) in all central towns of Punjab Pakistan with end products sink in water bodies. Habitat loss due to high exposure to insecticides is one of primary factors contributing to amphibian population decline. The extensive industrial and domestic uses of CYP promote many questions about their undesirable health effects. Due to its lipophilic nature CYP affects the immune, cardiovascular, nervous and reproductive systems of organisms in addition to inducing mutagenicity and carcinogenicity with adverse health effects. Current study is designed to investigate the histopathological effect of CYP on target organs of frog as biomarkers of toxicity in frog organs. The frogs were experimentally exposed to sub-lethal concentration (7.5µg/L) of Alpha-cypermethrin 10% SC for 14 days. Present study demonstrates health effects that have been associated with exposure to alpha-cypermethrin in terms of damages in kidney, spleen, heart and tongue of frog.
Keywords: Alpha-cypermethrin; Frog; Histopathology; Insecticides; Pyrethroid; Toxicity