7. Impact of cypermethrin on blood profile, tissue redox parameters and the observation of histopathological changes in the liver of Rabbit (Oryctolagus cuniculus)

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Farzeen Saeed, Razia Iqbal


The present study was conducted to examine the effects of Cypermethrin on the blood profile, tissue redox parameters and the histopathological changes in the liver of rabbit. 36 male rabbits were randomly divided into three treatment groups and orally administered concentrations of Cypermethrin was provided to them per unit of body weight; Treatment group A; T1 (300mg/kg), Treatment group B; T2 (600mg/kg), Treatment group C; T3 (900mg/kg) and group D; T0 (Control group). The blood profile of these rabbits showed that there was a noteworthy decrease in the Hb, RBCs, Hct, MCV, MCH and MCHC of the rabbits. The number of platelets and WBCS increased as the concentration of Cypermethrin increased. The catalase activity also increased in a dose dependent manner with the highest activity seen at the chemical concentration of 900mg/kg. Histopathological studies showed that Cypermethrin caused necrosis, congestion, vacuolization and tissue degeneration in the livers of almost all the treatment groups. On the basis of these results, it was concluded that Cypermethrin is not safe for animals, so finding alternatives to these pesticides is a prerequisite to prevent toxicity in animals and humans alike.

Keywords: Cypermethrin; Histopathological; Necrosis; Pyrethroids; Tissue redox; Toxicity


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