Antioxidant and antimicrobial activities of Iso-steviol: a derivative of Stevioside

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Syeda Jawairya Hashmi, Syeda Safia Hashmi, Anila Ghani, Aliya Aqeel, Muhammad Ibrahim Syeda Asma Taskeen, Syed Salman


Stevioside is a diterpene glycoside and natural sweetener extracted from plant stevia rebeudiana Bertoni (family Asteraceae). It is a low calorie sugar substitute and is identified as highly intense sweetener which is almost 50-100 times more sweetener as compared to sucrose. Iso-steviol, an important derivative of Stevioside which serve as non-caloric sugar. The Antioxidant, antifungal and antibacterial activities of iso-steviol were studied in this research work. A variety of bacterial and fungal species were tested in this work and were compared to standard clinical drugs. Iso-steviol was also evaluated for free radicals scavenging potential i.e. antioxidant power using standard DPPH protocol. Iso-steviols exhibited high free radical scavenging power i.e. 84% at a concentrating of µg/mL. The result revealed that the extract showed marked potential against S. aureus and E. coli while the extracts were found moderate against P. aeruginosa and S. typhi. Iso-steviol exhibited noticeable antifungal activity against A.niger and A.alternita while least active against A.solani and A.terreus. So it is concluded that the iso-steviol shows some more positive effects and will help against different diseases. Nevertheless, further studies are suggested for exact mechanism of action.

Keywords: DPPH; Iso-steviol;  Stevia rebeudiana Bertoni; Stevioside

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