Detection of differentially expressed proteins in sera of patients with hepatocellular carcinoma by sodium dodecyl sulphate poly-acrylamide gel electrophoresis (SDS-PAGE)

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Farah Sabeen Bugti, Mohammad Zahid Mustafa*, Tauseef Muhammad Asmat, Asadullah, Bibi Zainab, Safiullah Khan Achakzai, Muhammad Rizwan, Abdul Samad, Muhammad Kamran Taj, Nadeem Rashid


Hepatocellular carcinoma (HCC) is considered as one of the major liver cancers prevailing in the world. The survival rate for the patients diagnosed with HCC is very low as average survival time is only one year. Due to the lack of early diagnosis and poor knowledge of pathophysiological mechanisms, screening of HCC remains possible only at advanced stages. Furthermore, due to non-effective treatment and poor diagnostic techniques led to high fatality rate. Previously, number of HCC markers has been identified but have very less specificity. This study was designed to look into and find out certain HCC specific serological proteins which may be used as biomarker for the early diagnosis of the said disease. In this study all collected samples were analyzed by SDS-PAGE. The results revealed that four different proteins were up-regulated in HCC diagnosed patients compared to the control sample. These proteins may be used as potential biomarkers for the early diagnosis of HCC. The further investigations of the relevant proteins may reveal important clues for the early diagnosis of HCC.

Keywords: Biomarker proteins; HCC; SDS-PAGE; Early diagnosis; Liver Cancer

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