10. Effect of glyphosate on hematological and biochemical parameters of Rabbit (Oryctolagus cuniculus)

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Sanam Naz, Razia Iqbal Aftab Ahmad Muhammad Faheem Malik Muhammad Jabbar Rashid Yaqoob Muhammad Saeed Abid Hussain, Tahir Aziz, Syed Usman Haider and Abdul Razaq



To improve agriculture, herbicides are extensively used all over the world. In this study toxicity of glyphosate was assessed on rabbits. For this reason, 36 female rabbits were divided into four groups including treated and control having 9 rabbits in each. Three concentrations of glyphosate were selected as BC1 (50mg/kg/bw), BC2 (100mg/kg/bw) and BC3 (150mg/kg/bw) for treated groups and no any treatment for the control group C. For checking the herbicide effects hematological parameters including white blood cells (WBC), red blood cells (RBC), hemoglobin, hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and platelets and biochemical parameters including bilirubin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase, urea and creatinine were selected. The rabbits were exposed to glyphosate and effect of glyphosate was studied after 15,30 and 45 days of exposure. This study indicated that glyphosate showed remarkable toxicity for hematological and biochemical parameters under investigation and glyphosate toxicity was directly related to the increasing concentration and time of exposure.

Keywords: Biochemical parameters; Glyphosate; Hematological parameters; Herbicides or pesticides; Rabbit; Toxicity


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