82. Elemental, antimicrobial and antioxidant activities of a medicinal plant Sorghum halepense

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Abdul Yasar Khayal, Inam Ullah, Muhammad Nughman Syed Majid Shah Nawab Ali



Sorghum halepense (L.) Pers belongs to the family Graminae or Poaceae, known as Grass family and is an important medicinal plant. It is used as fodder for animals. Present study is designated to find out medicinal properties of this plant. For this purpose the plant samples were collected and acid digested to evaluate the concentration of heavy metals such as iron (Fe), copper (Cu), manganese (Mn), zinc (Zn), lead (Pb), cadmium (Cd), chromium (Cr), and nickel (Ni) using atomic absorption spectrophotometer. Presence of heavy metals is important for medicinal plants. Then antibacterial, antifungal and antioxidant activities in Sorghum halepense was evaluated by macerating and shed drying the plant sample for fifteen days and crude extract, ethyl acetate, n-hexane, chloroform and aqueous fractions were extracted. After careful analysis the concentration of heavy metals were determined as high except Cd and Cr. The crude extract and other fractions of sorghum halepense showed good antibacterial activities against P. aeruginosa, S. epidermidis, Escherichia coli, K. pneumonia and B.  subtillus but some of the fractions were not active against some of the bacterial strains. All the fractions showed antifungal activity against Aspergillus niger, Aspergillus fumigatus and Aspergillus flavus except ethyl acetate and aqueous fraction. The ethyl acetate, n-hexane and aqueous fractions showed excellent 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity but crude extract and chloroform  didn’t show this activity. This plant has shown various positive medicinal attributes and could be used for further bioassays and for isolation of safe herbal drugs.

Keywords: Acid digestion; Crude extract; Heavy metals; Herbal plants; Resistance; Weed


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