1. Peste des petits ruminants: A review

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Abdul Kabir, Dildar Hussain Kalhoro Shahid Hussain Abro, Muhammad Saleem Kalhoro, Haider Ali Yousafzai Sheeba Shams Ihsan Ullah Khan Ghulam Murtaza Lochi, Muhammad Qasim Mazari, Muhammad Waseem Baloch Arab Khan Lund Mujeeb ur Rehman Memon


Peste-des-petits-ruminants (PPR) is a notifiable, contagious and economically important transboundary viral disease of small ruminant causing high morbidity and mortality. It belongs to negative-sense, single-stranded RNA paramyxovirus of genus Morbillivirus. PPR occurs in populations of immunologically naive sheep and goats, illness and death can be high as >90%. The virus is commonly found in developing countries, especially in tropical countries where the disease is widespread. After the eradication of the rinderpest virus, which is closely relate to PPRV of small ruminants contaminated with SRMV are diagnosed having pyrexia, oculo-nasal discharges, necrotizing and erosive stomatitis, gastroenteritis, diarrhea and broncho pneumonia, whereas, gross pathology, histological findings along with laboratory confirmation of specific virus antigen, antibodies, genome in the clinical samples through a variety of serological and molecular diagnostic tests can be useful. In addition there should be social economic surveys, disease hot spot recognition and identification of role of additional species in disease transmission. SRMV control may be achieved by confinement of contaminated animals, subtraction of theoretically tainted fomites with control at import and export of sheep with goats from contaminated areas. PPR can be controlled through mass vaccination program. In the future, the preparation of a marker vaccine with a robust companion test may assist in serosurveillance for the detection of infection in vaccinated animals to control the disease.

Keywords: Control; Epidemiology; Goat; Peste des petits ruminants; Sheep; Vaccination


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