51. Histopathological effects of galanin on reproductive hormones and reproductive organs of rabbit (Oryctolagus cuniculus)

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Suleman Hussain Shah, Razia Iqbal, Mubashar Hussain, Muhammad Faheem Malik, Bilal Mukhtar, Muhammad Saqib Sajid


Effects of galanin, on reproductive hormones and histopathology of reproductive organs of rabbit was assessed by exposing adult rabbits to low, medium and high doses of 0.2, 0.4 and 0.8 µg/ml per kg body weight, respectively. Adult rabbits were reared and managed separately in cages (2 x 2 x 2 m3) under controlled conditions of photoperiod (12 light: 12 dark) whereas temperature was maintained at 23 ± 2 oC. The measured quantities of Alfalfa fodder plant as a sole food was provided to all groups simultaneously with free access to water. The increase in the weight of testes and ovaries was recorded in males and females, respectively. The histopathological examination of gonads revealed no adverse effects, however, the significant differences in the levels of testosterone (4.21ng/dl, 4.33ng/dl, 4.57 ng/dl), estrogen (123.33 pg/ml, 135.33 pg/ml, 151.33 pg/ml) and progesterone (196.33 ng/ml, 217.00 ng/ml, 229.33 ng/ml) were recorded in the low, medium and high dose treated groups, respectively. The increase in the aggressive sexual behavior was noticed which correlated with the increase in the concentration of reproductive hormones. Galanin had no negative effects on the testes and the ovaries of rabbits but induced the production of reproductive hormones in addition to the increase in the weight of gonads.

Keywords: ELISA; Estrogen; Gonads; Testosterone


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